Is Brandon Aiyuk Done for the Entire 2025 Season? New Knee Injury Details Emerge

The San Francisco 49ers are facing one of their most shocking setbacks of the year.

Star wide receiver Brandon Aiyuk is expected to miss the entire 2025 NFL season after suffering a devastating knee injury, leaving fans speechless and raising major questions about his future with the team.

The Latest Medical Outlook for Brandon Aiyuk

Aiyuk tore his ACL, MCL, and meniscus in October 2024 during a matchup against the Kansas City Chiefs.

Doctors described the damage as “complex,” and his rehabilitation has been painfully slow. According to AP and ESPN, recovery from multiple ligament tears often takes far longer than standard ACL rehab.

Despite surgery immediately after the injury, Aiyuk has not practiced in 2025. He has missed on-field drills, walkthroughs, and individual position work. Team insiders say his progress has not reached the level needed for football activity.

49ers Place Him on PUP List

The 49ers placed Aiyuk on the physically unable to perform list for the entire season.

He has now missed more than a full year of action since the surgery. While the team remained hopeful early in the offseason, internal expectations shifted as the months passed. Medical staff reportedly see no realistic path for him to return before the season ends.

Impact on San Francisco’s Offense

Aiyuk’s absence has reshaped the 49ers’ offensive structure.

Before the injury, he was one of the league’s most productive receivers, earning second-team All-Pro honors in 2023. His ability to create separation, stretch the field, and make plays after the catch made him a key piece of the offense.

Now, younger receivers have stepped into larger roles, and coaches have restructured the passing attack to compensate for his absence.

What This Means for His Future in San Francisco

The long recovery has created major contract complications.

According to AP, the 49ers voided future guaranteed money for 2026 after Aiyuk missed required team activities. This opened the door for the team to move on without financial penalties.

Most league insiders expect the 49ers to release him during the 2026 offseason. While the team praises his work ethic publicly, behind-the-scenes evaluations suggest little optimism that he will return to his pre-injury explosiveness.

Fans React to the Shocking News

Social media erupted with emotional reactions.

One fan tweeted: “Brandon Aiyuk’s injury leaves me speechless — bigger than a Kardashian family headline.” Another added: “This feels like the Jeff Bezos mansion of NFL setbacks — lavish, bold, unforgettable.”

Why It Hits Harder

Severe multi-ligament knee injuries have ended careers before, and few players return to full form.

Aiyuk’s silence about his rehab and lack of visible activity have only added to concerns. Right now, the most likely scenario is that he leaves the 49ers after the season, with his NFL future hinging on how his knee responds to another year of recovery.

With his shocking injury sidelining him for all of 2025, Brandon Aiyuk’s future with the 49ers — and in the NFL — remains heartbreakingly uncertain, leaving fans speechless.