Grey’s Anatomy Shock: James Pickens Jr. Reveals Real-Life Cancer Battle in 2025

Veteran Grey’s Anatomy actor James Pickens Jr. revealed he has been diagnosed with prostate cancer, just days after his character Dr. Richard Webber received the same diagnosis on the show. The 73-year-old, who has starred on the ABC medical drama since its 2005 premiere, noted that the disease runs in his family and was detected early thanks to regular screening. In a candid interview with Black Health Matters, Pickens shared his decision to undergo a prostatectomy and urged others — especially Black men and those with a family history — to talk to their doctors about testing. His disclosure has sparked a renewed conversation about cancer awareness in both his real life and the world of Grey’s Anatomy.

Diagnosis & Medical Background

James Pickens Jr., best known for his long-running role on Grey’s Anatomy, confirmed he has prostate cancer, a disease that has afflicted multiple men in his family. He explained that his father and uncles also battled prostate cancer, making early testing a priority. Thanks to his diligence, the cancer was detected before it had spread beyond the prostate. Pickens said his medical team identified a rare variant of the disease, and he opted for a radical prostatectomy to address it.

On the show, his character Dr. Richard Webber mirrored this diagnosis during the series’ mid-season finale, opening a storyline in which Webber grapples with his illness and his legacy at the hospital. The parallel between fiction and real life underscores how Pickens is leveraging his platform to raise awareness.

Quotes & Reactions

“It’s not the kind of news anyone wants to hear, but to be honest, prostate cancer has run through my family,” Pickens told Black Health Matters. He added, “My urologist said … because you were being tested, we were able to catch it so early … to your advantage.”

Pickens referenced his extensive family history, noting, “I’ve got a 90-year-old first cousin … a couple of his brothers had it. No one, as far as I know, has succumbed to it.”

Acknowledging the racial disparities in healthcare, he said, “If you’re Black, or prostate cancer runs in your family, talk to your doctor about getting screened starting at age 40. Today, I am living proof that early detection works.”

Broader Implications

Pickens’ announcement carries significant weight in both the entertainment world and public health space. Within the Grey’s Anatomy community, the alignment of his real-life diagnosis with his character’s arc offers a powerful example of art and reality converging. For audiences, especially Black men, his transparency may encourage earlier and more frequent screening, potentially saving lives through early intervention.

In the broader television landscape, this moment bolsters the reputation of Grey’s Anatomy as a show willing to tackle serious, real-world medical issues. Pickens’ openness may also inspire other actors and public figures to share personal health battles, reducing stigma around cancer and medical testing.

Health Advocacy & On-Screen Future

Pickens said he hopes his story will prompt more men to get regular prostate exams and discussions with their physicians. Medical organizations and cancer advocacy groups may leverage his disclosure to amplify prostate cancer education, particularly in underrepresented communities.

On the narrative side, Grey’s Anatomy writers may continue to explore Dr. Webber’s illness in upcoming episodes, reflecting Pickens’ recovery journey or prognosis. Meanwhile, fans and colleagues are likely to rally in support, using the platform of the show to highlight the importance of early detection.

Sources

• ESPN

• 247Sports

• On3